Structure and function of Polo-like kinases
نویسندگان
چکیده
منابع مشابه
Polo-like kinases
cycle with terminal differentiation. A unipotent host cell population acts as stem cells, which proliferate and migrate from the center of each lobule to the periphery, cease division, and die through apoptosis. During this journey they carry along their symbionts, which divide in the center, stop dividing, and subsequently become digested in the periphery. Digestion thus serves both in host no...
متن کاملSchistosoma mansoni Polo-like kinases and their function in control of mitosis and parasite reproduction.
Polo-like kinases are important regulators of cell cycle progression and mitosis. They constitute a family of conserved serine/threonine kinases which are highly related in their catalytic domains and contain polo boxes involved in protein-protein interactions and subcellular localization. In mammals, five Plks (Plk 1-5) encompass diverse roles in centrosome dynamics, spindle formation, intra S...
متن کاملPolo-like kinases in cell cycle checkpoint control.
Recent studies from various eukaryotic model systems indicate that polo-like kinases (Plks) play an ever-increasing role in the regulation of cell cycle progression. Early genetic studies have demonstrated that Cdc5, a budding yeast counterpart of vertebrate Plks, is essential for mitosis. Mammalian Plks primarily localize to the microtubule organization center during interphase and undergo dra...
متن کاملCloning and characterization of Plx2 and Plx3, two additional Polo-like kinases from Xenopus laevis.
Members of the family of Polo-like kinases are implicated in the regulation of cell cycle progression in all eukaryotes. In Xenopus laevis, only one member of this family, Plx1, has previously been described. Here we report the cloning and characterization of X. laevis Plx2 and Plx3, the likely homologs of mammalian Plk2 (Snk) and Plk3 (Fnk/Prk), respectively. RNA expression studies indicate th...
متن کاملStructure-function relationship of the Polo-like kinase in Trypanosoma brucei.
Polo-like kinases (Plks) play multiple roles in mitosis and cytokinesis in eukaryotes and are characterized by the C-terminal Polo-box domain (PBD), which is implicated in binding to Plk substrates, targeting Plk and regulating Plk activity. The Plk homolog in Trypanosoma brucei (TbPLK) possesses a similar architecture, but it lacks the crucial residues involved in substrate binding and regulat...
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ژورنال
عنوان ژورنال: Oncogene
سال: 2005
ISSN: 0950-9232,1476-5594
DOI: 10.1038/sj.onc.1208280